JPS53137940A - Polyene compounds - Google Patents

Polyene compounds

Info

Publication number
JPS53137940A
JPS53137940A JP5241878A JP5241878A JPS53137940A JP S53137940 A JPS53137940 A JP S53137940A JP 5241878 A JP5241878 A JP 5241878A JP 5241878 A JP5241878 A JP 5241878A JP S53137940 A JPS53137940 A JP S53137940A
Authority
JP
Japan
Prior art keywords
polyene compounds
polyene
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5241878A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6332777B2 (en]
Inventor
Peter Loeliger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JPS53137940A publication Critical patent/JPS53137940A/ja
Publication of JPS6332777B2 publication Critical patent/JPS6332777B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/38—Alcohols containing six-membered aromatic rings and other rings and having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5456—Arylalkanephosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP5241878A 1977-05-04 1978-05-02 Polyene compounds Granted JPS53137940A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU77254A LU77254A1 (en]) 1977-05-04 1977-05-04

Publications (2)

Publication Number Publication Date
JPS53137940A true JPS53137940A (en) 1978-12-01
JPS6332777B2 JPS6332777B2 (en]) 1988-07-01

Family

ID=19728555

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5241878A Granted JPS53137940A (en) 1977-05-04 1978-05-02 Polyene compounds

Country Status (32)

Country Link
US (1) US4193931A (en])
JP (1) JPS53137940A (en])
AR (1) AR220704A1 (en])
AT (1) AT356647B (en])
AU (1) AU522598B2 (en])
BE (1) BE866651A (en])
BR (1) BR7802807A (en])
CA (1) CA1114830A (en])
CH (2) CH641755A5 (en])
CS (1) CS214853B2 (en])
CU (1) CU21105A (en])
DE (1) DE2819213A1 (en])
DK (1) DK155730C (en])
ES (2) ES469394A1 (en])
FI (1) FI66587C (en])
FR (1) FR2390428A1 (en])
GB (2) GB1600914A (en])
GR (1) GR74426B (en])
HU (1) HU183088B (en])
IE (1) IE46946B1 (en])
IL (2) IL54590A (en])
IT (1) IT1096278B (en])
LU (1) LU77254A1 (en])
MC (1) MC1193A1 (en])
MY (1) MY8500250A (en])
NL (1) NL7804773A (en])
NO (1) NO148290C (en])
NZ (1) NZ187114A (en])
PH (1) PH14216A (en])
PT (1) PT67988B (en])
SE (1) SE436644B (en])
ZA (1) ZA782415B (en])

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07112952A (ja) * 1993-09-02 1995-05-02 F Hoffmann La Roche Ag 芳香族カルボン酸誘導体及び皮膚・粘膜治療剤
KR20200060459A (ko) * 2017-09-28 2020-05-29 존슨 앤드 존슨 컨수머 인코포레이티드 화장 조성물 및 피부 치료 방법

Families Citing this family (51)

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US4216312A (en) * 1978-08-24 1980-08-05 Hoffmann-La Roche Inc. Furyl substituted polyenes
FI67386C (fi) * 1979-06-21 1985-03-11 Hoffmann La Roche Foerfarande foer framstaellning av nya terapeutiskt anvaendbara sockerderivat
CH651007A5 (de) * 1982-06-24 1985-08-30 Hoffmann La Roche Polyenverbindungen.
DK158947C (da) * 1982-07-06 1991-01-21 Hoffmann La Roche Tetrahydronaphthalin-,benzofuran- og benzothiophenderivater, fremstilling og anvendelse deraf samt rodenticid indeholdende saadanne derivater
US4529600A (en) * 1982-09-09 1985-07-16 Sri International Pentadeuterioretinoids
US4439614A (en) * 1982-09-22 1984-03-27 Sri International 5,6-Methano-5,6-dihydroretinoids
US4464389A (en) * 1982-10-20 1984-08-07 Sri International Esters of retinoic acid and pentaerythritol and monobenzal acetals thereof
US4539154A (en) * 1983-06-15 1985-09-03 Hoffmann-La Roche Inc. Polyene compounds
CH661516A5 (de) * 1983-12-08 1987-07-31 Hoffmann La Roche Phenylnonatetraenoylzuckerderivate.
US4783549A (en) * 1984-09-05 1988-11-08 L'oreal Benzonorbornene derivatives, processes for their preparation and medicinal and cosmetic compositions containing them
FR2580277B1 (fr) * 1985-04-15 1988-06-10 Oreal Nouveaux derives naphtaleniques a action retinoique, le ur procede de preparation et compositions medicamenteuse et cosmetique les contenant
US5030764A (en) * 1986-05-23 1991-07-09 Hoffmann-La Roche Inc. Novel tetrahydronaphthalene and indane derivatives
US5030765A (en) * 1986-05-23 1991-07-09 Hoffmann-La Roche Inc. Novel tetrahydronaphthalene and indane derivatives
ZW7487A1 (en) * 1986-05-23 1987-12-16 Hoffmann La Roche Tetrahydronaphthaline and indane derivatives
AT388728B (de) * 1987-03-17 1989-08-25 Hoffmann La Roche Neue tetrahydronaphthalin- und indanderivate
US5250562A (en) * 1988-02-24 1993-10-05 Hoffmann-La Roche Inc. Stilbene derivatives
US5248696A (en) * 1991-04-18 1993-09-28 World Research Institute For Science And Technology, Inc. Composition and method for treating tumors
US7655699B1 (en) 1992-04-22 2010-02-02 Eisai Inc. Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US5780676A (en) * 1992-04-22 1998-07-14 Ligand Pharmaceuticals Incorporated Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
FR2719041B1 (fr) * 1994-04-26 1996-05-31 Cird Galderma Nouveaux composés polyéniques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
JP4001913B2 (ja) * 1994-12-30 2007-10-31 リガンド・ファーマシューティカルズ・インコーポレイテッド 新規なトリエンレチノイド化合物および方法
US7115728B1 (en) * 1995-01-30 2006-10-03 Ligand Pharmaceutical Incorporated Human peroxisome proliferator activated receptor γ
CA2233888A1 (en) * 1995-10-06 1997-04-10 Ligand Pharmaceuticals Incorporated Dimer-selective rxr modulators and methods for their use
US6112489A (en) * 1995-12-12 2000-09-05 Monotech International, Inc. Monocoque concrete structures
AU4080597A (en) * 1996-08-23 1998-03-06 Board Of Regents For Oklahoma State University, The Heteroarotinoids-anticancer agents with receptor specificity and tgase activity
FR2752837B1 (fr) * 1996-09-02 1999-11-12 Cird Galderma Nouveaux composes modulateurs des recepteurs hormonaux, les compositions les comprenant et leur utilisation en therapie
WO1999005161A1 (en) * 1997-07-25 1999-02-04 Ligand Pharmaceuticals Incorporated HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPARη) GENE REGULATORY SEQUENCES AND USES THEREFOR
US6534545B1 (en) 1997-09-25 2003-03-18 Galderma Research & Development Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and cosmetics
FR2768731B1 (fr) 1997-09-25 1999-12-10 Cird Galderma Derives insatures en position -4 du 6-tert-butyl-1,1- dimethylindane et leur utilisation en medecine humaine ou veterinaire ainsi qu'en cosmetique
WO1999063980A1 (en) * 1998-06-12 1999-12-16 Ligand Pharmaceuticals Inc. Treatment of anti-estrogen resistant breast cancer using rxr modulators
IL148045A0 (en) * 1999-08-27 2002-09-12 Ligand Pharm Inc Androgen receptor modulator compounds and methods
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
CA2378298A1 (en) 1999-08-27 2001-03-08 Lawrence G. Hamann 8-substituted-6-trifluoromethyl-9-pyrido¬3,2-g|quinoline compounds as androgen receptor modulators
EP1216221A2 (en) * 1999-09-14 2002-06-26 Ligand Pharmaceuticals Incorporated Rxr modulators with improved pharmacologic profile
US7842727B2 (en) * 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US6495719B2 (en) * 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
US6586460B1 (en) 2001-04-02 2003-07-01 The Board Of Regents For Oklahoma State University Heteroarotinoids containing urea or thiourea linker
AU2003243272A1 (en) * 2002-05-22 2003-12-12 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
WO2004046104A2 (en) * 2002-11-20 2004-06-03 Errant Gene Therapeutics, Llc Treatment of lung cells with histone deacetylase inhibitors
US9050310B2 (en) * 2004-06-25 2015-06-09 Minas Theodore Coroneo Treatment of ocular lesions
CA2587013A1 (en) * 2004-11-08 2006-05-18 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US20060204474A1 (en) * 2005-02-25 2006-09-14 Coroneo Minas T Treatment of epithelial layer lesions
WO2012076842A1 (en) * 2010-12-09 2012-06-14 University Of Durham Synthetic retinoids for control of cell differentiation
US11045441B2 (en) 2015-10-13 2021-06-29 Wisconsin Alumni Research Foundation Use of retinoic acid and analogs thereof to treat central neural apneas
US10966948B2 (en) 2019-07-23 2021-04-06 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
AU2019311846B2 (en) * 2018-07-27 2023-02-23 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
US11197841B2 (en) 2019-07-23 2021-12-14 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
US20200030226A1 (en) 2018-07-27 2020-01-30 Johnson & Johnson Consumer Inc. Botanical and bacterial extracts displaying retinol-like activity
US11969454B2 (en) 2019-11-19 2024-04-30 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452085A (en) * 1966-02-11 1969-06-24 Carbo Erba Spa Alpha-(5-indanyl)-butyric acid
US3781314A (en) * 1971-07-14 1973-12-25 Hoffmann La Roche Polyene compounds
BE793108A (fr) * 1971-12-22 1973-06-21 Hoffmann La Roche Derives polyeniques
US3957836A (en) * 1973-07-02 1976-05-18 Takeda Chemical Industries, Ltd. Quinone derivatives
CH582668A5 (en]) * 1973-08-10 1976-12-15 Hoffmann La Roche
CH585709A5 (en]) * 1973-08-24 1977-03-15 Hoffmann La Roche
CH592598A5 (en]) * 1973-10-30 1977-10-31 Hexachimie
AR206619A1 (es) * 1974-02-07 1976-08-06 Hexachimie Procedimiento para peparar acidos 5-indanilaceticos
FR2276035A1 (fr) * 1974-06-28 1976-01-23 Lipha Nouveaux derives de l'indane
JPS51125235A (en) * 1974-09-26 1976-11-01 Hoffmann La Roche Preparation of polyene compounds
US4054589A (en) * 1974-09-26 1977-10-18 Hoffmann-La Roche Inc. Novel 9-substituted phenyl-3,7-dimethyl-nona-2,4,6,8-tetraene esters

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07112952A (ja) * 1993-09-02 1995-05-02 F Hoffmann La Roche Ag 芳香族カルボン酸誘導体及び皮膚・粘膜治療剤
KR20200060459A (ko) * 2017-09-28 2020-05-29 존슨 앤드 존슨 컨수머 인코포레이티드 화장 조성물 및 피부 치료 방법
JP2020535202A (ja) * 2017-09-28 2020-12-03 ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッドＪｏｈｎｓｏｎ ＆ Ｊｏｈｎｓｏｎ Ｃｏｎｓｕｍｅｒ Ｉｎｃ． 化粧品組成物及び皮膚の処置方法

Also Published As

Publication number Publication date
PH14216A (en) 1981-04-02
AU3576278A (en) 1979-11-08
CA1114830A (en) 1981-12-22
NL7804773A (nl) 1978-11-07
ES475240A1 (es) 1979-05-16
CU21105A (es) 1981-12-04
FR2390428A1 (fr) 1978-12-08
SE7805136L (sv) 1978-11-05
LU77254A1 (en]) 1979-01-18
DK155730B (da) 1989-05-08
NO781586L (no) 1978-11-07
IL54590A (en) 1982-02-28
GR74426B (en]) 1984-06-28
BR7802807A (pt) 1979-01-02
ZA782415B (en) 1979-04-25
IT7823003A0 (it) 1978-05-04
FI781227A7 (fi) 1978-11-05
CH641755A5 (de) 1984-03-15
DK155730C (da) 1989-10-02
JPS6332777B2 (en]) 1988-07-01
GB1600915A (en) 1981-10-21
DK195378A (da) 1978-11-05
IL61697A0 (en) 1981-01-30
IE46946B1 (en) 1983-11-16
NZ187114A (en) 1980-11-14
HU183088B (en) 1984-04-28
AT356647B (de) 1980-05-12
NO148290C (no) 1983-09-14
US4193931A (en) 1980-03-18
BE866651A (fr) 1978-11-03
MY8500250A (en) 1985-12-31
NO148290B (no) 1983-06-06
GB1600914A (en) 1981-10-21
IL54590A0 (en) 1978-07-31
PT67988A (en) 1978-06-01
ES469394A1 (es) 1979-02-01
FI66587B (fi) 1984-07-31
CH642380A5 (de) 1984-04-13
MC1193A1 (fr) 1979-02-23
IT1096278B (it) 1985-08-26
AU522598B2 (en) 1982-06-17
PT67988B (en) 1980-05-05
DE2819213A1 (de) 1978-11-16
SE436644B (sv) 1985-01-14
ATA320478A (de) 1979-10-15
FI66587C (fi) 1984-11-12
CS214853B2 (en) 1982-06-25
IE780864L (en) 1978-11-04
AR220704A1 (es) 1980-11-28
FR2390428B1 (en]) 1983-03-04
DE2819213C2 (en]) 1987-09-24

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